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| Date | Round | Time | Home | Score | Away |
|---|
| October 2010 |
| 30/10/2010 | Round 1 | 14:30 | Aberavon Quins RFC | v | Aberavon Green Stars RFC |
| 30/10/2010 | Round 1 | 14:30 | Abertillery / Blaenau Gwent RF | v | Pill Harriers RFC |
| 30/10/2010 | Round 1 | 14:30 | Blaina RFC | v | Ynysybwl RFC |
| 30/10/2010 | Round 1 | 14:30 | BP R.F.C (Llandarcy) RFC | v | Brynamman RFC |
| 30/10/2010 | Round 1 | 14:30 | Brecon RFC | v | Nantyffyllon RFC |
| 30/10/2010 | Round 1 | 14:30 | Caernarfon RFC | v | Bro Ffestiniog RFC |
| 30/10/2010 | Round 1 | 14:30 | Dowlais RFC | v | Fairwater RFC |
| 30/10/2010 | Round 1 | 14:30 | Dunvant RFC | v | Cwmllynfell RFC |
| 30/10/2010 | Round 1 | 14:30 | Fleur de Lys RFC | v | Penallta |
| 30/10/2010 | Round 1 | 14:30 | Garndiffaith RFC | v | Abergavenny RFC |
| 30/10/2010 | Round 1 | 14:30 | Haverfordwest RFC | v | Newcastle Emlyn RFC |
| 30/10/2010 | Round 1 | 14:30 | Llandeilo RFC | v | Kidwelly RFC |
| 30/10/2010 | Round 1 | 14:30 | Llantwit Fardre RFC | v | Pentyrch RFC |
| 30/10/2010 | Round 1 | 14:30 | Loughor RFC | v | Mumbles RFC |
| 30/10/2010 | Round 1 | 14:30 | Mountain Ash RFC | v | Abercynon RFC |
| 30/10/2010 | Round 1 | 14:30 | Pwllheli RFC | v | Colwyn Bay RFC |
| 30/10/2010 | Round 1 | 14:30 | Tondu RFC | v | Builth Wells RFC |
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